MASHINIi

AN2 Therapeutics, Inc..

ANTX.US | Manufacture of pharmaceuticals, medicinal chemical and botanical products

AN2 Therapeutics, Inc. is a biopharmaceutical company focused on developing and commercializing novel therapies for rare, chronic, and infectious diseases with high unmet needs. Their lead product candidate is epetraborole, an oral treatment for patients with nontuberculous mycobacterial (NTM) lung ...Show More

Ethical Profile

Mixed.

AN2 Therapeutics demonstrates a commitment to global health by developing treatments for neglected tropical diseases like Chagas and NTM lung disease. Their Global Health Agreement caps product prices at cost plus 25% for global access, with tiered pricing for low-income patients. The company also received a grant from the Bill & Melinda Gates Foundation. However, as a biopharmaceutical firm, its drug development inherently involves animal testing. Reports also indicate a significant 50% workforce reduction. Data on environmental impact, ethical sourcing, or comprehensive worker respect metrics is limited.

Value Scores

Better Health for All20
-100100
Fair Money & Economic Opportunity0
-100100
Fair Pay & Worker Respect0
-100100
Fair Trade & Ethical Sourcing0
-100100
Honest & Fair Business-50
-100100
Kind to Animals-60
-100100
No War, No Weapons0
-100100
Planet-Friendly Business0
-100100
Respect for Cultures & Communities0
-100100
Safe & Smart Tech0
-100100
Zero Waste & Sustainable Products0
-100100

Better Health for All

20

The company's core business is focused on developing novel therapies for rare, chronic, and infectious diseases with high unmet needs, including NTM lung disease and neglected tropical diseases like Chagas disease, indicating an entire business devoted to health improvement.

1
For its Global Access Products, the company has agreed to a maximum price capped at cost of sales plus 25%, and implements tiered pricing based on buyer type and geographic location to reflect the price sensitivity of low-income patients.
2

Fair Money & Economic Opportunity

0

AN2 Therapeutics is a biopharmaceutical company focused on developing and commercializing novel therapies. The provided articles detail financial results, clinical trial updates, and grant agreements for disease research. There is no evidence that the company offers lending, deposit, insurance, or other financial services to consumers. Therefore, all KPIs related to fair money and economic opportunity, which are designed for financial institutions, are not applicable to AN2 Therapeutics.

Fair Pay & Worker Respect

0

The provided articles do not contain specific, concrete data points for any of the Fair Pay & Worker Respect KPIs. While some articles state that no regulatory actions, violations, fines, or compliance issues are mentioned within their content,

1
this is not considered a concrete data point for scoring the 'labor_violation_incidents' KPI, as it refers to the absence of information in the articles rather than a definitive statement about the company's record. Information regarding living wage, CEO to median pay ratio, collective bargaining, safety incident rates, pay equity, worker engagement, voluntary turnover, insecure contracts, or health insurance coverage is not available.
2

Fair Trade & Ethical Sourcing

0

No specific data regarding ANTX.US's fair trade and ethical sourcing practices, supplier certifications, audit frequencies, incidents of forced or child labor, supply chain traceability, remediation speed, ethical clause coverage in contracts, materials risk, or supplier diversity spend was found in the provided articles.

1
The articles discuss general industry challenges and best practices but do not offer company-specific quantitative metrics for ANTX.US.
2

Honest & Fair Business

-50

AN2 Therapeutics has a confidential and anonymous financial concern hotline and a secure web form for reporting complaints regarding accounting, internal accounting controls, or auditing matters.

1
The Audit Committee oversees and reviews the company's Whistleblower Policies and establishes procedures for confidential and anonymous submissions.
2
The company made a non-cash adjustment of $0.6 million to correct stock-based compensation expense for the first and second quarters of 2025, which was not material to previously issued financial statements.
3
The company identified material weaknesses in its internal control over financial reporting.
4
Pomerantz LLP is investigating claims of securities fraud or other unlawful business practices against AN2 and its officers/directors, triggered by a 74.50% stock price drop on February 12, 2024, following a voluntary pause in a Phase 3 clinical trial due to potentially lower than expected efficacy.
5
The Nominating and Corporate Governance Committee charter, effective November 15, 2024, states that each committee member shall be free from any relationship that would interfere with independent judgment, as determined by the Board, in accordance with Nasdaq requirements.
6
The company has an Anti-Corruption Policy, which the Audit Committee periodically reviews and monitors for compliance.
7
The Global Health Agreement also contains anti-corruption requirements.
8

Kind to Animals

-60

The company undertakes pre-clinical studies on animals to examine the safety profile of its medications.

1
Its lead product candidate, epetraborole, has demonstrated efficacy in animal models of NTM infection.
2
There is no evidence that the company employs non-animal testing methods for product safety and efficacy. The company's policy involves animal testing for pre-clinical studies.
3

No War, No Weapons

0

No specific, concrete data points relevant to the 'No War, No Weapons' ethical value were found in the provided articles. Sustainability data for AN2 Therapeutics, Inc. is explicitly stated as unavailable, preventing any assessment of the relevant metrics.

1

Planet-Friendly Business

0

No specific environmental, social, or governance (ESG) metrics or sustainability data for AN2 Therapeutics, Inc. (ANTX.US) were found in the provided articles. Multiple sources explicitly state that sustainability data is not available for the company.

1

Respect for Cultures & Communities

0

No specific, concrete data points relevant to ANTX.US or the 'Respect for Cultures & Communities' value were found in the provided article. The article discusses the launch of a B2B thought leadership platform by Digital Journal and general statistics about B2B thought leadership, which is unrelated to AN2 Therapeutics, Inc.'s operations or community engagement.

1

Safe & Smart Tech

0

No evidence available to assess AN2 Therapeutics, Inc. on Safe & Smart Tech.

Zero Waste & Sustainable Products

0

No specific evidence was found in the provided articles regarding AN2 Therapeutics, Inc.'s performance or initiatives related to waste diversion, product recyclability, packaging sustainability, recycled content, single-use plastic reduction, take-back programs, circular design principles, waste reduction initiatives, hazardous waste management, product durability, repairability, waste audit frequency, zero waste certification, waste disposal violations, material efficiency, packaging to product ratio, waste reduction targets, supplier waste requirements, or customer waste education.

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AI-generated analysis based on publicly available data. Not financial advice. Ratings are expressions of opinion derived from automated models and may contain inaccuracies. See our Risk Disclosure for full details.