MASHINIi

Neuropace, Inc..

NPCE.US | Manufacture of medical and dental instruments and supplies

NeuroPace, Inc. is a commercial-stage medical device company focused on developing, manufacturing, and marketing products for the treatment of neurological disorders. Its primary product is the RNS System, a closed-loop brain-computer interface that delivers personalized, responsive neurostimulation...Show More

Ethical Profile

Mixed.

Neuropace, Inc. (NPCE.US) receives a mixed ethical rating, primarily driven by its significant impact on patient health. The company's RNS system has demonstrated substantial benefits for drug-resistant epilepsy patients, with reports showing an 82% median reduction in seizures over three years, and 42% of patients achieving seizure freedom for six months or more. Neuropace's commitment to innovation is underscored by a Q1 2025 R&D expense of $7.4 million. However, critics point to a lack of available information regarding the RNS system's price accessibility and reach to vulnerable populations. While one adverse event report detailed a lead fracture, the patient reportedly experienced no consequences. Other ethical areas, including fair pay, ethical sourcing, and environmental impact, lack sufficient public data for assessment.

Value Scores

Better Health for All20
-100100
Fair Money & Economic Opportunity0
-100100
Fair Pay & Worker Respect0
-100100
Fair Trade & Ethical Sourcing0
-100100
Honest & Fair Business0
-100100
Kind to Animals-60
-100100
No War, No Weapons0
-100100
Planet-Friendly Business0
-100100
Respect for Cultures & Communities0
-100100
Safe & Smart Tech-10
-100100
Zero Waste & Sustainable Products0
-100100

Better Health for All

20

NeuroPace's core product, the RNS System, demonstrates significant positive health impacts for drug-resistant focal epilepsy. A 3-year post-approval study showed an 82% median reduction in seizures and 42% of patients achieved seizure freedom for 6+ months.

1
A 9-year study reported 35% of patients achieved at least 90% seizure frequency reduction and 28% had seizure-free periods, with lower SUDEP rates compared to refractory populations.
2
The company's R&D expense was $7.4 million in Q1 2025, representing 32.9% of its $22.5 million revenue for the quarter, indicating a strong investment in health innovation.
3
The company has received FDA approval for its RNS System.
4
The company's website includes safety information and advises consulting a doctor about risks and benefits.
5
However, specific adverse event rates from the 3-year post-approval study, for which safety and effectiveness data were submitted to the FDA in November 2024, are not provided.
6
A single adverse event report from 2017 detailed a lead fracture, though it resulted in no consequences or impact to the patient.
7

Fair Money & Economic Opportunity

0

No evidence available to assess Neuropace, Inc. on Fair Money & Economic Opportunity.

Fair Pay & Worker Respect

0

No evidence available to assess Neuropace, Inc. on Fair Pay & Worker Respect.

Fair Trade & Ethical Sourcing

0

No quantitative evidence was found in the provided articles to assess Neuropace, Inc. against the Fair Trade & Ethical Sourcing value. outlines a Supplier Code of Conduct detailing expectations for ethical sourcing, labor practices, and environmental responsibility, including prohibitions against forced and child labor, and mandates for risk assessments and audits.

1
However, this document is a policy statement and does not provide specific data points on performance metrics such as the percentage of fair-trade certified spend, audit frequency, number of labor incidents, supply chain traceability, remediation speed, or the percentage of contracts with ethical clauses.
2
Articles and were inaccessible due to throttling.
3

Honest & Fair Business

0

No evidence available to assess Neuropace, Inc. on Honest & Fair Business.

Kind to Animals

-60

NeuroPace conducted animal studies, including lead implantation in sheep for 33 to 200 days, and biocompatibility testing in rabbits and guinea pigs.

1
These studies involved various device components and assessed neurotoxicity, local tissue responses, and systemic effects.
2
A separate study used eight male, castrated Suffolk sheep with survival periods of 6-9 months.
3
While the company performed in-vitro cytotoxicity testing, it also relied on extensive animal studies for safety assessments.
4
The company advocates for alternative testing methods like 'brains-on-chips' and 'human imaging techniques'.
5
There is no explicit company-wide animal testing policy stated in the provided articles.
6
The company does not mention participation in multi-stakeholder initiatives for animal-free R&D or active engagement in animal welfare policy improvement.
7

No War, No Weapons

0

No evidence available to assess Neuropace, Inc. on No War, No Weapons.

Planet-Friendly Business

0

No evidence available to assess Neuropace, Inc. on Planet-Friendly Business.

Respect for Cultures & Communities

0

No specific, quantitative data points related to NeuroPace, Inc.'s respect for cultures and communities were found in the provided articles.

1
The available information explicitly states that sustainability data is unavailable and no quantitative data relevant to the requested metrics is presented.
2

Safe & Smart Tech

-10

NeuroPace encrypts data in transit and at rest for its nSight Platform and mentions data encryption as a general cybersecurity measure.

1
The company has no documented data breaches or incidents of unauthorized data use.
2
Users can request deletion of their data, subject to exceptions, and data portability is available, along with opt-out options for marketing materials.
3
Login credentials are required for access, and the company mentions user names, passwords, and access controls.
4
NeuroPace has a risk management process that includes vulnerability management and incident response, with reporting to the audit committee for certain incidents.
5
Security testing includes penetration testing, with third-party providers utilized.
6
The company states it collects only necessary data, but specific data minimization practices or retention schedules are not detailed.
7
NeuroPace mentions compliance with the HIPAA Security Rule and addresses CCPA for California residents, but explicitly states it does not claim GDPR compliance for personal data.
8

Zero Waste & Sustainable Products

0

No specific, quantifiable evidence was found in the provided articles to assess Neuropace, Inc. against any of the 'Zero Waste & Sustainable Products' KPIs. While one article mentioned 'recyclable device components' and 'eco-friendly manufacturing practices',

1
these statements lacked the specific percentages, numbers, or detailed outcomes required to score against the rubric's quantitative thresholds for product recyclability, waste diversion, or other related metrics.

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AI-generated analysis based on publicly available data. Not financial advice. Ratings are expressions of opinion derived from automated models and may contain inaccuracies. See our Risk Disclosure for full details.