MASHINIi

Trevi Therapeutics, Inc..

TRVI.US | Manufacture of pharmaceuticals, medicinal chemical and botanical products

Trevi Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing and commercializing innovative therapies for chronic pruritus (itch) and other chronic conditions. Their primary focus is on developing Haduvio™ (nalbuphine ER) for the treatment of pruritus associated with ...Show More

Ethical Profile

Mixed.

Trevi Therapeutics, a biopharmaceutical company developing Haduvio for chronic cough and pruritus, presents a mixed ethical profile. While their core mission aims to improve health, the company's environmental practices draw attention. In 2023, Trevi reported 1,876 metric tons of CO2e emissions. Its Sustainalytics ESG Risk Rating of 37.9 ranks it 726 out of 847 in the pharmaceuticals industry, suggesting high ESG risk and weak management compared to peers. On the positive side, 37% of their energy was renewable in 2023, with a 45% target by 2025, and 92% of clinical trial waste was bio-hazardously disposed.

Value Scores

Better Health for All20
-100100
Fair Money & Economic Opportunity0
-100100
Fair Pay & Worker Respect-30
-100100
Fair Trade & Ethical Sourcing0
-100100
Honest & Fair Business0
-100100
Kind to Animals-70
-100100
No War, No Weapons0
-100100
Planet-Friendly Business-20
-100100
Respect for Cultures & Communities0
-100100
Safe & Smart Tech10
-100100
Zero Waste & Sustainable Products0
-100100

Better Health for All

20

Trevi Therapeutics is a clinical-stage biopharmaceutical company focused on developing Haduvio (nalbuphine ER) for chronic cough in patients with Idiopathic Pulmonary Fibrosis (IPF) and Refractory Chronic Cough (RCC).

1
These conditions significantly impair patients' quality of life, leading to social, physical, and psychological decline, and can increase the risk of progression, death, or lung transplant in IPF.
2
There are currently no FDA-approved therapies for chronic cough in IPF or RCC in the U.S., indicating a focus on unmet medical needs.
3
The company's entire business is devoted to developing this therapy, which has the potential to significantly improve patient quality of life. Clinical trials are conducted under strict rules and regulations to ensure ethical treatment of participants.
4
However, the company's expanded access outside of ongoing clinical trials is not currently available.
5
While the target populations, IPF (approximately 150,000 in the U.S.) and RCC (approximately 2-3 million adults in the U.S.),
6
are vulnerable due to their health conditions, the articles do not provide data on the extent to which low-income or marginalized populations specifically obtain equitable access.

Fair Money & Economic Opportunity

0

Trevi Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on drug development, not financial services.

1
The provided articles contain no evidence related to the company offering lending, deposit, or other financial services to consumers. Therefore, there is no data to assess any of the KPIs under the 'Fair Money & Economic Opportunity' value, as they are all designed for financial institutions.

Fair Pay & Worker Respect

-30

As of December 31, 2021, Trevi Therapeutics had 24 employees.

1
None of the employees are represented by labor unions or covered by collective bargaining agreements.
2
The company offers health, welfare, and quality of life benefits, including a 401(k) plan with matching contributions of 50% on the first 6% of elective contributions, paid time off, and personal leave.
3
The company benchmarks its total rewards against industry peers.
4
Employees are expected to report violations of law or the Code of Business Conduct and Ethics to management or via an anonymous hotline, with a policy against retaliation for good-faith reports.
5

Fair Trade & Ethical Sourcing

0

No evidence available to assess Trevi Therapeutics, Inc. on Fair Trade & Ethical Sourcing.

Honest & Fair Business

0

No evidence available to assess Trevi Therapeutics, Inc. on Honest & Fair Business.

Kind to Animals

-70

The company's preclinical testing includes animal studies for its medical products, services, research, and therapies.

1
Nalbuphine ER, a key drug candidate, has shown efficacy in both animal studies and human clinical trials.
2
There is no evidence of any non-animal testing methods being employed.
3
The company is listed for exploiting animals due to its animal testing practices, and there is no evidence of a formal animal testing policy.
4

No War, No Weapons

0

No evidence available to assess Trevi Therapeutics, Inc. on No War, No Weapons.

Planet-Friendly Business

-20

In 2023, 37% of the company's operational energy consumption was sourced from renewables.

1

Respect for Cultures & Communities

0

No specific, concrete data points were found in the provided articles to assess Trevi Therapeutics, Inc. against the KPIs for 'Respect for Cultures & Communities'. The articles primarily consist of general company information

1
, an internal code of conduct
2
, and SEC filings
3
, none of which detail formal partnerships with community groups, revenue reinvested locally, cultural appropriation incidents, cultural impact assessment protocols, local employment ratios, community-specific grievance mechanisms, or other relevant metrics as defined by the rubric. Information regarding grievance mechanisms pertains to internal code violations rather than community concerns
4
, and cultural training refers to understanding the Code of Conduct, not cultural sensitivity
5
.

Safe & Smart Tech

10

The company's GDPR data protection notice, last updated March 20, 2023, outlines user rights including access, rectification, restriction, erasure, portability, and withdrawal of consent.

1
It states that data is kept only as long as necessary for the stated purpose.
2
The notice also confirms compliance with EU, EEA, Switzerland, and UK data protection laws, using standard contractual clauses for data transfers to the US.
3
The website privacy notice, also updated March 20, 2023, reiterates GDPR compliance for EU users and allows users to opt-out of marketing emails.
4

Zero Waste & Sustainable Products

0

No evidence available to assess Trevi Therapeutics, Inc. on Zero Waste & Sustainable Products.

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AI-generated analysis based on publicly available data. Not financial advice. Ratings are expressions of opinion derived from automated models and may contain inaccuracies. See our Risk Disclosure for full details.