Better Health for All

Tyra Biosciences is a precision oncology company entirely focused on developing therapies to overcome cancer resistance and improve outcomes for patients with cancer, including treatments for FGFR-related cancers and achondroplasia.

This means 100% of its portfolio is aimed at delivering revolutionary health benefits, with no evidence of harmful products since its incorporation in 2018. The company's prospectus includes a "Risk Factors" section detailing numerous risks associated with drug development, clinical trials, regulatory approval, and commercialization. The company acknowledges being subject to laws governing the privacy and security of sensitive information, including GDPR and CCPA/CPRA, with potential fines up to 4% of global annual revenue or €20 million for non-compliance. Clinical trials are conducted in accordance with Good Clinical Practices (GCP), and all research subjects provide informed consent. New guidance expected in 2025 requires sponsors to submit a diversity plan for trials, especially in oncology, with the FDA scrutinizing enrollment demographics for TYRA-300 trials to ensure adequate representation of racial and ethnic minorities.

Fair Pay & Worker Respect

Based on the available evidence, Tyra Biosciences' alignment with fair pay and worker respect is difficult to assess comprehensively. The CEO's compensation of $4.63 million in 2023 is noted

, and the CEO compensation is above average for similar-sized US companies . However, the CEO-to-median-employee pay ratio is not available in the provided sources. Glassdoor.com has employee reviews, but no quantitative data on the requested metrics . Without data on living wages, pay equity, safety, or labor incidents, a neutral score is not appropriate. Given the limited data and the above-average CEO compensation, a slightly negative score is more appropriate. Therefore, a score of -10 is assigned, reflecting limited transparency and potential concerns, but not definitive evidence of misalignment.

Fair Trade & Ethical Sourcing

The provided articles, which consist of corporate governance guidelines, a proxy statement, terms of use, and a code of conduct, do not contain specific, quantitative, or concrete qualitative data regarding Tyra Biosciences' fair trade and ethical sourcing practices. There is no information on fair-trade certifications, supplier audit frequency, forced or child labor incidents, supply chain traceability, remediation speed for violations, the percentage of procurement budget directed to diverse suppliers, or the share of spend on high-risk materials.

While the company's Code of Conduct and Ethics outlines internal ethical expectations for employees and directors, including fair dealing with suppliers and compliance with general laws, it does not provide evidence of enforceable ethical-sourcing clauses within supplier contracts or details on supply chain management practices.

Planet-Friendly Business

Tyra Biosciences, Inc. states a commitment to managing its assets in a manner protective of human health, safety, and the environment, and a policy to comply with applicable environmental laws and regulations.

However, the provided articles do not contain specific, measurable data points for any of the Planet-Friendly Business KPIs, such as emissions, renewable energy use, water consumption, waste diversion, or environmental certifications. Therefore, no KPIs can be scored.

Respect for Cultures & Communities

The company has a confidential Ethics Hotline available 24/7 for anonymous reporting of suspected violations of its Code of Business Conduct and Ethics or applicable laws and regulations.

The Audit Committee is responsible for implementing, maintaining, and monitoring this hotline, and for investigating reports received through it. This constitutes a standard grievance process. The company is engaging with the achondroplasia community, including advocates and physicians, as it works to initiate the BEACH301 study. While the General Counsel or Chief Financial Officer may require employees to donate gifts to an appropriate community organization, there is no specific percentage of company revenue or non-core revenue allocated to cultural heritage organizations or community development funds.

Safe & Smart Tech

Tyra Biosciences states it complies with the General Data Protection Regulation (GDPR), UK GDPR, and California Civil Code Section 1798.83 ("Shine The Light Law").

The company provides contact information for EU and UK Data Protection Representatives and a Data Protection Officer (DPO) in Germany. Users residing in the EEA/UK have rights to access, correct, erase, restrict processing, and ensure data portability, as well as the right to revoke consent and object to processing based on legitimate interests. The company collects basic contact details (name and e-mail address) and automatically collects IP address, device, mobile network, standard web, and security information. It retains personal data for ordinary business activities, legal obligations, dispute resolution, and legitimate business purposes, with information potentially stored in aggregated and anonymized format after retention periods. The company explicitly states that automated decision-making or profiling in accordance with Art. 22 GDPR does not take place.