Upstream Bio, Inc..
UPB.US | Manufacture of pharmaceuticals, medicinal chemical and botanical products
Upstream Bio, Inc. is a biopharmaceutical company focused on developing novel therapies for inflammatory diseases. The company's lead product candidate, UPB-101, is designed to target and block the thymic stromal lymphopoietin receptor (TSLPR), a key driver of inflammation in various diseases such a...Show More
Better Health for All
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Upstream Bio's core business is focused on developing novel therapies for inflammatory diseases. Its lead product candidate, verekitug, has shown substantial health benefits in early clinical studies for asthma patients, including a 54% reduction in fractional exhaled nitric oxide concentration (FENO) and similar reductions in blood eosinophils, sustained for up to 24 weeks.
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The company is currently conducting three Phase 2 placebo-controlled, randomized clinical trials for verekitug in severe asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), and chronic obstructive pulmonary disease (COPD), involving nearly 670 adult patients for COPD alone.
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The company publishes a privacy notice for clinical study participants, detailing data collection, processing, storage, sharing, and privacy rights, demonstrating excellent data practices.
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Clinical trials are described as randomized and placebo-controlled, suggesting adherence to ethical practices and informed consent procedures.
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Fair Money & Economic Opportunity
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No evidence available to assess Upstream Bio, Inc. on Fair Money & Economic Opportunity.
Fair Pay & Worker Respect
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No specific, concrete data points were found in the provided articles for any of the KPIs under the 'Fair Pay & Worker Respect' value. While executive compensation figures for fiscal year 2024 were available, the crucial median employee compensation data required to calculate the CEO to median pay ratio was not provided.
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For all other KPIs, including living wage coverage, collective bargaining share, safety incident rates, pay equity ratios, worker engagement scores, employee turnover rates, labor violation incidents, insecure contract share, and health insurance coverage, no quantitative data or specific metrics were available.
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Fair Trade & Ethical Sourcing
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No data regarding Upstream Bio, Inc.'s fair trade and ethical sourcing practices could be extracted from the provided articles. All articles indicated that the requested webpages were unavailable, unrelated, or contained no relevant information.
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Honest & Fair Business
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No evidence available to assess Upstream Bio, Inc. on Honest & Fair Business.
Kind to Animals
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No specific, concrete evidence regarding Upstream Bio, Inc.'s practices or policies related to animal welfare, animal testing, or animal-derived inputs could be found in the provided articles. Information about the company's general ethical standards or the FDA's regulatory changes does not provide scorable data for the company's performance on the 'Kind to Animals' KPIs.
No War, No Weapons
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No evidence available to assess Upstream Bio, Inc. on No War, No Weapons.
Planet-Friendly Business
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No specific, concrete data points for Upstream Bio, Inc. (UPB.US) were found across any of the provided articles for the Planet-Friendly Business KPIs. The articles discuss general industry trends, other companies' sustainability efforts, or broad sector challenges, but do not provide any direct evidence of UPB.US's environmental performance, targets, or initiatives.
Respect for Cultures & Communities
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No specific, concrete evidence was found in the provided articles regarding Upstream Bio, Inc.'s performance on any of the KPIs related to Respect for Cultures & Communities. The articles either discuss general ethical considerations in biotechnology and clinical trials, provide examples of other companies' practices (e.g., Variant Bio, UC Berkeley), or focus on Upstream Bio's internal company culture and clinical trial activities without addressing its engagement with local or indigenous communities, cultural preservation, or related financial contributions.
Safe & Smart Tech
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No evidence available to assess Upstream Bio, Inc. on Safe & Smart Tech.
Zero Waste & Sustainable Products
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No specific data or information regarding Upstream Bio, Inc.'s performance on waste diversion, product recyclability, packaging sustainability, recycled content, single-use plastic reduction, take-back programs, circular design principles, waste reduction initiatives, hazardous waste management, product durability, repairability, waste audit frequency, zero waste certification, waste disposal violations, material efficiency, packaging to product ratio, waste reduction targets, supplier waste requirements, or customer waste education could be found in the provided articles.
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